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pentobarbital will lower the extent or result of saxagliptin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.pentobarbital will lessen the level or outcome of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.With therapeutic doses of TCAs, barbiturates increase metabol